ABSTRACT
Background: the male breast cancer [MBC] is a rare disease and represents less than 1% of all malignancies in men and less than 1% of all breast cancers incident
Aim of study: in this descriptive retrospective study we aimed to provide clinic-epidemiological characteristics of MBC. To present the treatment given with respect to DFS, TTP and OS, to identify possible prognostic factors of the disease and the toxicities encountered by the treatment given
Patients and Method: out of 11313 cancer patients 3046 were breast cancer; 28 of them were MBC. All patients presented to clinical oncology department in Ain Shams University in the period from January 2008 to December 2014 and follow up till December 2016
Results: the median age of patients was 59 years. Around 90% had hormone receptor positive [estrogen and/or progesterone receptors].Two third of the patients had advanced T-stage [T3 and T4]. Infiltrating ductal carcinoma the most common type of histology was encountered. Modified radical mastectomy was the most common [75%] type of surgery done followed by chemotherapy for 21 patients and loco-regional radiotherapy for 20 patients. Tamoxifen was administered in 19 patients. Relapse occurred in 14 patients [50%]. The 5-year disease-free survival [DFS] was 21.4%, the 5-year time to progression [TTP] rate was 21.4% and the 5-year old overall survival [OS] rate was 35.7%
Conclusion: there is always a delay in the male patients since the first complaint until they seek medical advice, which results in an advanced disease at presentation
ABSTRACT
Surgical treatment has evolved over the past ten years particularly for cancer involving the mid and lower third of the rectum. carcinomas of the lower third of the rectum are usually treated by abdominoperineal resection especially for T3 lesions. Few data are available evaluating Concomitant chemotherapy with preoperative radiotherapy for increasing sphincter saving resection [SSR] in low rectal cancer The purpose of this study was to evaluate the possibility of SSR for T3 cancers of the lower third of the rectum and subsequently the complication oncologic and functional results of preoperative chemoradiation followed sphincter saving procedure is assessed and determined. Twelve patients with T3 rectal carcinoma were treated by preoperative radiation with concomitant chemotherapy were included in the study. All patients had invasive adenocarcinoma of the rectum and underwent staging before treatment by endorectal ultrasonography All patients underwent conservative surgey after chemoradiation for low rectal cancer tumors located at a mean of 5 cm from the anal verge. Transanal intersphincteric resection was done in 7 patients. A colonic J-pouch was done in 2 patients. All patients had a defunctioning loop ileastomy. There were no deaths related to preoperative chemoradiation or surgery. Morbidity occurred in 33.3% of patients was complicated by a pelvic abscess that responded to conservative treatment. The other complications local recurrence at the anastomosis site at 13 months and was treated by salvage APR After preoperative chemoradiation all the tumors appeared as an ulcerative scar without any vegetative component. The mean tumor size in fresh specimens was 3.6 cm range [l-9]. The mean distal margin, assessed in fresh specimens without traction, was 23 +/- 8 mm [range 10-40]. The mean radial margin assessed microscopically was 8 +/- 4 mm [range 1-20]. Both distal and radial margins were negative [> 2 mm] in 11 [91.6%] patients; they were positive [